A Comparison of Methods of Improving the Duty Cycle on Orthogonal TOF Mass Analyzers
When a continuous ion source is coupled to an oa-ToF mass
analyser the duty cycle, or sampling efficiency, is typically about 25%
for the highest m/z ions. The duty cycle decreases for ions of lower
m/z in proportion to the square root of their m/z values. An
established method of increasing the duty cycle involves accumulating
ions from a continuous ion source and then extracting them in a pulse.
This can increase the duty cycle over a restricted mass range, but for
ions outside that range the duty cycle will be reduced.