Mixed-Mode SPE Eliminates Matrix Effects from Biological Samples

Library Number:
WA40495
Part Number:
WA40495
Author(s):
Ziling Lu;Diane M. Diehl;Claude R. Mallet;Jeffrey R. Mazzeo [Waters]
Source:
ASMS
Content Type:
Posters
Content Subtype:
ASMS
Compounds:
Propranolol; Niflumic acid
Matrix:
Rat Plasma
Related Products:
Matrix effects can cause significant errors in the accuracy and precision of bioanalytical methods. Some researchers have identified phospholipids as causing significant interference in LC/MS/MS analyses, and others have demonstrated the degree of ion suppression and enhancement of matrix components in LC/MS . In our study, we systematically pursued the causes of matrix effects, the degree of the effects and what sample preparation techniques work the best to eliminate these effects.

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