The Development of LC/MS Methods for Determination of Polar Drugs of Abuse in Biological Samples

Library Number:
WA20259
Part Number:
WA20259
Author(s):
Michael S Young, Kevin M Jenkins
Source:
HPLC 2002; Montreal; 5-6 June 2002
Content Type:
Posters
Content Subtype:
HPLC
SPE:
Oasis MCX 60 mg 3 cc Vac Cartridge
Sorbent:
Compounds:
Ecstacy, GHB, GBL, MDA, MDMA, HMMA, Date Rape Drug, Club Drugs
Column:
XTerra MS C18 3.5 µm Steel 2.1 mm 150 mm
Related Products:
 
The use of certain classes of drugs known collectively as club drugs has been increasing worldwide. This term refers to drugs being used by young adults at all-night dance parties such as raves or trances, dance clubs, and bars. Among the more popular drugs used for this purpose are gamma-hydroxybutyrate (GHB) and 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy). Disturbingly, there have been reports of the criminal use of GHB to facilitate sexual assault (date rape). The most common methods of analysis for these compounds utilize GC or GC-MS analysis after a cumbersome derivatization step. In this presentation, we will demonstrate LC-MS methods for the rapid and straightforward determination of GHB and MDMA and metabolites in biological fluids. Also, we will discuss the application of these methods for the determination of other drugs of abuse.

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