The Development of LC/MS Methods for Determination of Polar Drugs of Abuse in Biological Samples

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Michael S Young, Kevin M Jenkins
HPLC 2002; Montreal; 5-6 June 2002
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Oasis MCX 60 mg 3 cc Vac Cartridge
Ecstacy, GHB, GBL, MDA, MDMA, HMMA, Date Rape Drug, Club Drugs
XTerra MS C18 3.5 µm Steel 2.1 mm 150 mm
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The use of certain classes of drugs known collectively as club drugs has been increasing worldwide. This term refers to drugs being used by young adults at all-night dance parties such as raves or trances, dance clubs, and bars. Among the more popular drugs used for this purpose are gamma-hydroxybutyrate (GHB) and 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy). Disturbingly, there have been reports of the criminal use of GHB to facilitate sexual assault (date rape). The most common methods of analysis for these compounds utilize GC or GC-MS analysis after a cumbersome derivatization step. In this presentation, we will demonstrate LC-MS methods for the rapid and straightforward determination of GHB and MDMA and metabolites in biological fluids. Also, we will discuss the application of these methods for the determination of other drugs of abuse.

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