Metabonomic Profiling of Urine from Lysinuric Protein Intolerance Affected Mice

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Gaetano Corso (Medical Faculty of the University of Foggia, Foggia, Italy);Richard Lock, Stephen McDonald, John Shockcor (Waters);Maria Pia Sperandeo, Gianfranco Sebastio (University Federico II of Napoli, Napoli, Italy
IMSC 2006, Aug. 27-Sept. 1, Prague; The Belgian Society for Mass Spectrometry, February 16, 2007 K. U. Leuven, Belgium
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To elucidate the complex and mostly unknown pathophysiology of Lysinuric protein intolerance (LPI), a genetically modified mouse by disruption of Slc7a7 gene was generated (from Lexicon Genetics Incorporated; The Woodlands, Texas). In the present report we describe the urinary metabolic phenotype (metabonome) of the LPI mouse model by UPLC orthogonal acceleration Time of Flight Mass Spectrometry (UPLC oa-TOF-MS). This poster was presented at the 17th International Mass Spectrometry Conference (IMSC), Aug. 27-Sept. 1, 2006 in Prague.

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