Analysis of Complex Peptide Mixtures using a Mass Spectrometer Incorporating a Traveling Wave Ion Mobility Devices

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Diana Uria, Christopher Hughes, Steven Pringle, James Langridge, Kevin Giles, Jason Wildgoose and Robert H. Bateman
IMSC 2006, Aug. 27-Sept. 1, Prague
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Other Symposium
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In this poster we describe the use of an ion mobility spectrometer coupled with time-of-flight mass spectrometry for the separation and mass analysis of peptides. IMS provides an additional stage of separation and can improve signal to noise by the removal of singly charged background ions from multiply charged peptides. Post IMS fragmentation can be used to associate fragment ions with their precursor ions, providing extra specificity.

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