A Novel Ion-Accounting Algorithm for Protein Database Searches

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Guo-Zhong Li, Dan Golick, Marc V. Gorenstein, Johannes P.C Vissers, Jeffrey C. Silva, Scott J. Geromanos
HUPO 2006 October 28 - November 1 Long Beach, Ca
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Other Symposium
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Q-Tof Premier
A novel database search algorithm is described that is ideally suited for identifying proteins over a wide dynamic range. Alternate scanning LC-MS (LC-MSE)1,2 data from a nanoACQUITY UPLCTM chromatograph coupled with a Q-Tof Premier™ mass spectrometer is utilized in this search algorithm. The database search strategy (“Ion Accounting”) is a hierarchal, protein-centric search algorithm containing three incrementally stringent modules.

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