A Combined Metabonomics and Proteomics Approach to Biomarker Discovery for Schizophrenia Using Accurate Mass LC-MS

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Thérèse McKenna, Hilary Major, Christopher Hughes , J. Claereboudt, Johannes P.C. Vissers, Jeffrey T.J. Huang, Sabine Bahn, James Langridge
Proteome Analysis in Systems Biology December 7 - 8 Antwerp, Belgium
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In this study we employed a label free quantitative mass spectrometry-based approach to analyze the metabolic and protein profiles in cerebrospinal fluid (CSF) samples from first-onset, drug naïve schizophrenia patients and demographically-matched healthy controls. As collection of CSF is a highly invasive procedure matched serum samples, which can be collected more routinely, were also analysed for the presence of potential biomarkers.

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