Top-Down Sequencing—The use of Travelling wave and drift tube IMS separations for separating protein ion charge states and their fragments

Library Number:
720001965EN
Part Number:
720001965EN
Author(s):
Steven Pringle, Kevin Giles, Stormy L. Koeniger, J. Claereboudt, Stephen Valentine, Robert Bateman, David E Clemmer
Source:
Proteome Analysis in Systems Biology December 7 - 8 Antwerp, Belgium
Content Type:
Posters
Content Subtype:
Other Symposium
Related Products:
SYNAPT HDMS
Although extensive work involving the separation and characterization of protein and peptide ions has been carried out, few studies have examined the mobilities of fragment ions.  In this study, two new ion mobility spectrometry (IMS) techniques, travelling wave (TWIMS) and a tandem drift tube (TDTIMS) have been used to separate the ubiquitin fragment ions (formed by collision induced dissociation) prior to analysis by MS.

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