Metabolic Profiling of Brain, Cerebrospinal Fluid and Serum for Potential Biomarkers of Schizophrenia
In this study we employed a UPLC exact mass, electrospray mass
spectrometry-based metabonomic approach in conjunction with
multi-variate data analysis to study the metabolic profiles in post
mortem brain, cerebrospinal fluid (CSF) and sera samples from
first-onset, drug naïve schizophrenia patients and
demographically-matched controls. Initial studies on post mortem brain
extracts showed that schizophrenics could be readily
differentiated from controls. As CSF bathes the brain it was
postulated that the metabolite profile would reflect that of the brain.
However collection of CSF is a highly invasive procedure therefore sera
samples, which can be collected more routinely, were also analysed for
the presence of potential biomarkers of schizophrenia.