Advanced SPE Protocols for UPLC-MS-MS Determination of Enrofloxacin and Ciprofloxacin in Chicken Tissue at Sub-ppb Levels

Library Number:
WA43224
Part Number:
WA43224
Author(s):
Michael S. Young, Kimvan Tran, Kevin M. Jenkins [Waters]
Source:
HPLC 2006, June 17-23, San Francisco, CA
Content Type:
Posters
Content Subtype:
HPLC
Compounds:
Amitriptyline; Diltiazem; Labetalol; Quinine; Verapamil
Related Products:
 
Straightforward SPE protocols were used to prepare chicken tissue samples for analysis using UPLC-MS-MS. Tandem SPE using both cation and anion-exchange retention of the amphoteric fluoroquinolone antibiotics provides excellent sample enrichment and cleanup. UPLC-MS analysis was performed in electrospray negative mode without ion-pairing mobile phase. Lower detection limits and much faster analysis times were obtained compared with traditional HPLC

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