An Automated High Throughput Approach to Quantification of Multiple Compounds Using UPLC Coupled to Tandem Mass Spectrometry

Library Number:
720001753EN
Part Number:
720001753EN
Author(s):
Ed Sprake, Steve Preece (Waters)
Source:
ISSX 2006 June 4-7, 2006 Manchester, UK; LC/MS Montreux Symposium 2006 November 8 - 10 Montreux, Switzerland
Content Type:
Posters
Content Subtype:
ISSX
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We have demonstrated the feasibility of generating good quality quantitative data using a highly automated UPLC/ MS/MS methodology from samples in dirty matrix. From the data available UPLC/MS/MS gave between 2x and 3x improvement in signal/noise when compared to HPLC/MS/MS.The UPLC/MS/MS gave 3x the throughput of the HPLC/MS/MS method while giving highly comparable results.

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