A specific Gaucher disease biomarker chitotriosidase has been positively identified, quantified and its enzymeactivity determined. Principle component analysis can be applied to both the low and elevated energy data sets to rapidly access dataquality and identify trends. Clustering driven gene ontology searches provide a convenient means for classification of the peptides and proteins that exhibit a similar change profile from a complex data set. Protein signaturesbased on absolute protein concentrations allow for non-comparative analysis,which could potentially be extended to large-scale clinical research studies.
This poster was presented at ASMS 2006, Quantitation Techniques III.