High Throughput Identification of Reaction and Degradation Products Using Ultra Performance Liquid Chromatography and Time of Flight Mass Spectrometry

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Michael McCullagh1;Lena M von Sydow2
British Mass Spec Society Meeting, BMSS
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Other Symposium
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Ultra performance liquid chromatography (UPLC™) coupled to orthogonal acceleration time-of-flight mass spectrometry (oa-TOF-MS) enables increased sample throughput and selectivity. Reaction and degradation products were identified using reversed phase HPLC and UPLC™ coupled to oa-TOF-MS. Data illustrating analysis time reduction with improved chromatographic resolution will be presented. In addition using oa-TOF-MS, pure CID accurate mass fragmentation spectra will be shown.

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