A Study of Contributions from HPLC Vials To Ion Suppression/Enhancement in Electrospray Ionization

Library Number:
WA43207
Part Number:
WA43207
Author(s):
Claude R Mallet, Erin Chambers, Diane M. Diehl, Jeffrey R. Mazzeo [Waters]
Source:
Pittcon, March13-16, 2006
Content Type:
Posters
Content Subtype:
Pittcon
The mechanism of ion suppression is not well understood at this time, but several sources were identified, such as the sample matrix and chromatographic conditions. In some cases, the suppression effect results in a 95 % lost of signal; in other situations, enhancement of the signal is observed.

A method for quantitatively determining ion suppression from vials is discussed


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