A Study of Contributions from HPLC Vials To Ion Suppression/Enhancement in Electrospray Ionization
The mechanism of ion suppression is not well understood at this
time, but several sources were identified, such as the sample matrix
and chromatographic conditions. In some cases, the suppression effect
results in a 95 % lost of signal; in other situations, enhancement of
the signal is observed.
A method for quantitatively determining ion suppression from vials