A Novel Approach for Identification and Characterization of Glycoproteins using a Quadrupole Ion-Mobility Time-of-Flight Mass Spectrometer
A new class of mass spectrometer has been developed by Waters (Synapt HDMS) with the unique capability to fractionate biomolecules in the gas phase by size, shape, and charge prior to mass spectrometric detection. The unique design of Synapt HDMS system enables researchers to simplify complex samples and permit the in-depth characterization of hybrid structures (e.g. glycopeptides) within a single analysis. This poster shows specific applications to the analysis of glycopeptides by use of ion-mobility separations and Time Aligned Parallel (TAP) fragmentation.