Advances in Silica Technology for Reversed-Phase HPLC Packings
The performance of silica-based reversed-phase HPLC packings
has improved dramatically over the last decade. The key advances have
been in the critical performance dimensions of peak shape for bases,
reproducibility, low pH stability and high pH stability. We have
recently developed a new family of hybrid organic-inorganic silica
particles that offer striking improvements in high pH stability and
peak shape for bases. The chemistry behind this new hybrid silica will
be discussed and related to the improved chromatographic performance.
The use of these packings in rapid LC/MS analyses of pharmaceuticals
will be highlighted.