Advances in Silica Technology for Reversed-Phase HPLC Packings

Library Number:
991146
Author(s):
Tom Walter;Bonnie Alden;Pam Iraneta;Ed Bouvier;Judy Carmody;Ray Crowley;Ray Fisk;Jeff Grassi;Christina Gendreau;Zhiping Jiang;John O''Gara;Dan Walsh
Source:
HPLC''99; Granada Spain; 2 June 1999
Content Type:
Orals/Lectures
Content Subtype:
HPLC
Compounds:
Uracil; Propranolol; Butyl Paraben; Naphthalene; Acenaphthene; Amitriptyline; Nicotine; Propranolol; Methamphetamine; Amphetamine; Ibuprofen; Benzoic acid; Salicylic Acid; Doxepin; Nortriptyline; Trimipramine
Column:
XTerra RP18 5 µm Steel 4.6 mm 150 mm
The performance of silica-based reversed-phase HPLC packings has improved dramatically over the last decade. The key advances have been in the critical performance dimensions of peak shape for bases, reproducibility, low pH stability and high pH stability. We have recently developed a new family of hybrid organic-inorganic silica particles that offer striking improvements in high pH stability and peak shape for bases. The chemistry behind this new hybrid silica will be discussed and related to the improved chromatographic performance. The use of these packings in rapid LC/MS analyses of pharmaceuticals will be highlighted.

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