HRMS Quantitation of Oligonucleotides Using Xevo G2-XS QTof Mass Spectrometer

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Mark D. Wrona Suma, Veeramachineni
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Application Notes
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Application Notes
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In this application note, we outline the performance capabilities of the Xevo G2-XS QTof HRMS platform for oligonucleotides as well as compare typical bioanalytical figures of merit to the triple quadrupole platforms.The Xevo G2-XS QTof MS has been proven to be a sensitive platform able to generate high quality data for LC-MS-based quantitation with multiple acquisition modes, providing multiple options for quantifiable peaks. It enables the ability to fine tune selectivity with the MEW and to select isotopes/charge states appropriate for the assay.

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