HRMS Quantitation of Oligonucleotides Using Xevo G2-XS QTof Mass Spectrometer

Library Number:
APNT135091457
Part Number:
720007391EN
Author(s):
Mark D. Wrona Suma, Veeramachineni
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
 
 
Biopharmaceutical
 
 
 
 

In this application note, we outline the performance capabilities of the Xevo G2-XS QTof HRMS platform for oligonucleotides as well as compare typical bioanalytical figures of merit to the triple quadrupole platforms.The Xevo G2-XS QTof MS has been proven to be a sensitive platform able to generate high quality data for LC-MS-based quantitation with multiple acquisition modes, providing multiple options for quantifiable peaks. It enables the ability to fine tune selectivity with the MEW and to select isotopes/charge states appropriate for the assay.


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