Analysis Of Oligonucleotide Impurities On The Bioaccord LC-MS System With ACQUITY Premier

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Catalin Doneanu, Christopher Knowles, Jonathan Fox, Emma Harry, Ying Qing Yu, Joseph Fredette, Ann Grey, and Weibin Chen
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Here we demonstrate the use of a novel chromatographic system, equipped with a modified surface technology across its entire fluidic path [1-2], for analysis of modified synthetic oligonucleotides and their impurities. An automated workflow, suitable for both regulated and nonregulated laboratories, was implemented for rapid mass confirmation and purity analysis of modified oligonucleotides.

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