High Sensitivity Bioanalysis Using the Xevo TQ-XS Tandem Quadrupole Mass Spectrometer

Library Number:
APNT135083036
Part Number:
720007208EN
Author(s):
Billy J. Molloy, Robert S. Plumb
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
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A reproducible high sensitivity UPLC-MS/MS bioanalytical methodology is demonstrated using the Xevo TQ-XS Tandem Quadrupole Mass Spectrometer. A simple protein precipitation sample preparation was used for the detection of Midazolam and Imipramine down to 250 ag on column (0.2 pg/mL). This limit of detection was also shown to be reproducible across three separate UPLC-MS/MS systems. 


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