The method performance study data demonstrates a robust analytical method for the determination of oxyanions by direct injection of water samples onto an Anionic Polar Pesticide Column fitted in an ACQUITY UPLC I-Class PLUS System coupled to a Xevo TQ-XS. This application exceeds the new requirements in the EU Drinking Water Directive (EU DWD) coming into effect in late 20203, current WHO drinking water guidelines2, and US EPA National Primary Drinking Water Regulations.4 Limits of quantification for chlorate and perchlorate are 20 µg/L, for bromate 2 µg/L, and for chlorite 100 µg/L. For chlorate, this is 12.5 times lower than the proposed new EU DWD limit, for bromate 5 times lower and, for chlorite 2.5 times lower. Perchlorate is 2.5 times lower than the WHO recommended level. Retention time stability was proven over the course of the study with RSDs for all 4 oxyanions under 1% across all 6 method performance batches and retention time stability study. This short method time of 5 minutes with direct injection of samples allows for a high sample number throughput.