Practical Instrument Considerations for Ion-Exchange Chromatography-Mass Spectrometry (IEX-MS)

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Andrew Schmudlach, Samantha Ippoliti, Julien Bourquin, Matthew A. Lauber
Content Type:
Application Notes
Content Subtype:
Technical Notes
Related Products:
Biopharmaceutical Discovery

Native LC-MS with aqueous mobile phases suffers detrimental effects on data quality and instrument health when microbial contamination is introduced. The good hygiene protocols and suggested maintenance in this document will improve data quality and reduce the down time of instruments due to poor sensitivity or loss of chromatographic resolution as a result of contamination or salt deposits. If you are still struggling with poor data quality or instrument contamination, please contact Waters Technical Support services via iRequest.

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