Size Exclusion Chromatography Method Transfer from a Standard HPLC to an Arc HPLC System

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Zhimin Li, Paula Hong, and Patricia R. McConville
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This application brief demonstrates a size-exclusion chromatography (SEC) method transfer for monoclonal antibody (mAb) analysis from an industry-standard HPLC system to a Waters Arc HPLC System. Comparable retention time, percent area of monomer, high molecular weight species, and low molecular degradants and repeatability were obtained from both systems.


  • Seamless SEC method transfer across a standard HPLC system and Arc HPLC System
  • Arc HPLC System provides tight RSD for SEC analysis for size variants of a monoclonal antibody (mAb)

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