Ultra-Low Level Analysis of Aldosterone in Plasma Using the Xevo TQ-XS for Clinical Research

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Dominic Foley and Lisa Calton
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An analytically sensitive and selective clinical research method has been developed for the analysis of aldosterone in plasma using the Xevo TQ-XS Mass Spectrometer.

The Xevo TQ-XS enables the analysis of physiologically low levels down to 8 pmol/L of aldosterone while only using 200 μL sample volume. Excellent levels of precision across the calibration range have been demonstrated. Accuracy assessment using EQA samples has shown the method provides excellent agreement for aldosterone. Automation of the analytical method in combination with sample tracking capabilities of the liquid handler, using the Tecan File Converter and MassLynx LIMS Interface, improves laboratory workflow and reduces sample handling, which alleviates the potential for operator error.

For Research Use Only. Not for use in diagnostic procedures.

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