LC-MS/MS Method Development and Validation for the Quantitative Determination of Regulated Mycotoxins in Cereal Grain Flours Using Simplified Sample Preparation Conditions on Xevo TQ-XS

Library Number:
APNT135035321
Part Number:
720006685EN
Author(s):
Nicola Dreolin and Sara Stead
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
 
 
 
 
ACQUITY UPLC I-Class System

Here we describe the validation of a quantitative multi-mycotoxin method in wheat flour, which was further extended to a range of different cereal-based flours. The Waters™ Xevo TQ-XS Tandem Quadrupole Mass Spectrometer was chosen because it provides ultimate sensitivity and it allows the analyst to implement a simple sample preparation process, thus reducing the overall analysis time. The use of isotopically labelled internal standards was investigated to achieve better performance compared to the widely adopted external standard or standard addition methods. The analytical procedure was assessed according to criteria described by the amended European Commission Regulation No. 401/2006 and SANTE guidelines.


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