Intact Trastuzumab Monoclonal Antibody Quantification Using the Xevo G2-XS QTof High Resolution Mass Spectrometer

Library Number:
APNT134994628
Part Number:
720006379EN
Author(s):
Yun Wang Alelyunas, Henry Shion, Ian Edwards, and Mark Wrona
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Technical Notes
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This technology brief demonstrates the performance of the Xevo™ G2-XS QTof platform for intact level quantification of trastuzumab monoclonal antibody and the use of UNIFI™ for rapid data processing and analysis. In the present study, a monoclonal antibody, trastuzumab, was quantified at the intact level through integration of XICs, which follows common practice in small molecule and peptide bioanalysis. 


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