Botanical ingredients are widely used in dietary supplements, herbal medicines, cosmetics, and personal care products. Potential contamination or misidentification of plants has been a health concern due to the lack of standardization of production. The testing of botanical ingredients and processed products for authenticity is a challenging task due to their complex phytochemical constituents, the variation in chemical profiles from different locations, plant anatomy, age and harvest season, and the similar phytochemical profile of closely related species.
In this application note, the feasibility of using mass detection for authenticity testing is demonstrated in a study for North American (NA) black cohosh (Actaea racemosa). In this feasibility study, a method for botanical authentication was developed using the MS data collected by the ACQUITY QDa Mass Detector. The accuracy of this authentication method was evaluated in a blind test with four commercial black cohosh samples. The advantages of MS over using a evaporative light scattering detector (ELSD) are also highlighted.
See related application note: Automated 2-Dimensional Fingerprint Analysis for Routine Botanical Authentication Using the ACQUITY QDa Mass Detector (720006284en)