Using UPLC-MS/MS for the Determination of cTHC in Preserved Oral Fluid

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Rob Lee and Michelle Wood
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Application Notes
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Technical Notes
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This technology brief describes a simple, sensitive UPLC-MS/MS method for the determination of cTHC in oral fluid.

The increasing use of oral fluid in forensic and roadside drug testing has highlighted the need for a quick, sensitive, accurate, reliable, and robust method to quantify illicit drugs in this frequently used biological matrix. The use of preserved oral fluid allows for simple, supervised and non-invasive collection of a matrix which contains analytes commonly measured in such testing schemes.

The Xevo TQ-S micro has demonstrated the required analytical sensitivity to detect cTHC in preserved oral fluid at low pg/mL concentrations.

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