Modernization and Troubleshooting of the USP Organic Impurity Method for Cetirizine Hydrochloride Tablets: Demonstration of XBridge HILIC Robustness Capabilities Across HPLC and UHPLC Instruments

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Jyotsna Sehajpal and Jacob Fairchild
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A modernized version of the USP method for organic impurities in cetirizine HCl tablets has been demonstrated on four different LC systems from two different vendors. Similar results were obtained on the HPLC and UHPLC systems used. These experiments were all performed using the same XBridge HILIC Column, providing confidence that validated methods can be successfully transferred between different LC systems.

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