Building a Collision Cross Section Library of Pharmaceutical Drugs Using the Vion IMS QTof Platform: Verification of System Performance, Precision and Deviation of CCS Measurements

Library Number:
APNT134922945
Part Number:
720005903EN
Author(s):
Yun Wang Alelyunas, Kerri Smith, Gareth Cleland, Russell Mortishire-Smith, and Mark D. Wrona
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
Ultra High Sensitivity Bioanalysis
 
 
 
 
lcms_qc_reference_standard
 

The deviation and precision of a set of CCS measurements were determined on the Vion IMS QTof platform. CCS was measured for QC and 134 additional small molecule compounds.

The present study suggests that Vion is a robust platform for routine qualitative and quantitative analysis. The high accuracy in CCS and m/z measurement enables its utility for ion mobility and m/z-based compound identification and measurements.

 

The attached file supplements the featured application note. FDA 134 drugs CCS library contains all drugs measured in the application note in Excel format.

 


Title Format File Size
Download PDF PDF 935.8kB