Evaluation of Ion Ratios as an Additional Level of Confirmation in Accurate Mass Toxicology Screening

Library Number:
LITR134922443
Part Number:
720005866EN
Author(s):
Jeff Goshawk and Michelle Wood
Source:
Waters
Content Type:
Literature
Content Subtype:
White Papers

This white paper uses the analysis of several exogenous steroids in order to illustrate the ability of UNIFI to automatically determine ion ratios for detected fragments, and to demonstrate that these ratios can be used as an additional level of confirmation.

The expected ion ratios were determined automatically by UNIFI for a set of reference standards, and ion ratio tolerances were defined on an individual fragment basis. Ion ratios measured, for samples in which the four steroids had been spiked into authentic urine, were shown to be within the permitted tolerance of the expected values for all of the fragment ions.


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