High-Performance Vion IMS QTof for Monoclonal Antibody Intact and Subunit Mass Analysis

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Henry Shion and Ying Qing Yu
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Application Notes
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Application Notes
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This application note focuses on Vion system performance for intact mAb and subunit mass analysis, covering the sensitivity, mass accuracy, and consistency in relative quantitation of glycosylation while maintaining the data integrity. The complete system is comprised of an ACQUITY UPLC H-Class Bio System coupled to an ACQUITY UPLC Tunable Ultraviolet (TUV) Detector and a Vion IMS QTof Mass Spectrometer. Waters UNIFI Scientific Information System was used for automatic data acquisition, processing, and reporting.

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