Antibody Quantification Using ProteinWorks eXpress Digest Kits

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Paula Orens, Mary Lame, Sherri Naughton, and Erin Chambers
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Application Notes
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Technical Notes
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Recently there has been a trend towards using LC-MS for the bioanalytical quantification of peptide and protein therapeutics, however challenges exist such as assay sensitivity, small sample volume requirements, and laborious sample prep workflows.

We demonstrate the flexibility of ProteinWorks eXpress DirectDigest Kits for the quantification of monoclonal antibody (mAb) drugs (infliximab, trastuzumab, bevacizumab, adalimumab) and their applicability across a range of sample volumes by LC-MS/MS.

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