Antibody Quantification Using ProteinWorks eXpress Digest Kits

Library Number:
APNT134874212
Part Number:
720005575en
Author(s):
Paula Orens, Mary Lame, Sherri Naughton, and Erin Chambers
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Technical Notes
Related Products:

Recently there has been a trend towards using LC-MS for the bioanalytical quantification of peptide and protein therapeutics, however challenges exist such as assay sensitivity, small sample volume requirements, and laborious sample prep workflows.

We demonstrate the flexibility of ProteinWorks eXpress DirectDigest Kits for the quantification of monoclonal antibody (mAb) drugs (infliximab, trastuzumab, bevacizumab, adalimumab) and their applicability across a range of sample volumes by LC-MS/MS.


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