This application note highlights the comparison of Oasis PRiME HLB, a novel reversed-phase SPE sorbent, to several other of the most common commercially available reversed phase SPE devices, with respect to both analyte recovery and matrix effects.
Oasis PRiME HLB is designed to enable simple and fast SPE protocols while nearly eliminating endogenous phospholipids with a simple load-wash-elute strategy. Low and consistent matrix effects were obtained across the entire tested drug panel with Oasis PRiME HLB, while much higher matrix effects and variability were observed on other SPE devices, especially for the late eluting drugs.
Oasis PRiME HLB represents a distinct advance in SPE technology with higher recovery, lower variability, and lower matrix effects. This should also translate to longer column lifetimes and less mass spectrometer source maintenance.