Improvements in Recovery, Reproducibility, and Matrix Effects with Oasis PRiME HLB, a Novel Solid Phase Extraction Sorbent

Library Number:
APNT134869232
Part Number:
720005495EN
Author(s):
Dr. Xin Zhang, Dr. Jonathan P. Danaceau, and Dr. Erin E. Chambers
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
 
Forensic Toxicology
 
 
 

This application note highlights the comparison of Oasis PRiME HLB, a novel reversed-phase SPE sorbent, to several other of the most common commercially available reversed phase SPE devices, with respect to both analyte recovery and matrix effects.

Oasis PRiME HLB is designed to enable simple and fast SPE protocols while nearly eliminating endogenous phospholipids with a simple load-wash-elute strategy. Low and consistent matrix effects were obtained across the entire tested drug panel with Oasis PRiME HLB, while much higher matrix effects and variability were observed on other SPE devices, especially for the late eluting drugs.

Oasis PRiME HLB represents a distinct advance in SPE technology with higher recovery, lower variability, and lower matrix effects. This should also translate to longer column lifetimes and less mass spectrometer source maintenance.


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