Transfer of the HPLC Method for Related Substances Analysis of Metoclopramide HCl from an Agilent 1260 Infinity LC System to an ACQUITY Arc System

Library Number:
APNT134849844
Part Number:
720005420EN
Author(s):
Margaret Maziarz, Mark Wrona
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Technical Notes
Related Products:
 

This technology brief demonstrates the transfer of an HPLC method for related substances of metoclopramide HCl from an Agilent 1260 Infinity LC System to an ACQUITY Arc™ System by comparing chromatographic separation and system suitability results.

The HPLC method for metoclopramide and its related substances was successfully transferred from an Agilent 1260 Infinity LC System to an ACQUITY Arc System. The ACQUITY Arc System successfully replicated the quality of chromatographic separation obtained on the Agilent 1260 Infinity LC System and met the USP specifications for system suitability. Meeting the system suitability requirements is essential for laboratories to remain in compliance with the current Good Laboratory Practices regulations. Moreover, the ACQUITY QDa Detector, in conjunction with UV detection, enabled quick confirmation of peak identity by mass detection.

Overall, the ACQUITY Arc System delivers reliable, robust, and reproducible results, enhancing throughput and laboratory efficiency for routine testing in the QC laboratory.


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