A Simple, Fast, and Reliable LC-MS/MS Method for Determination and Quantification of Phthalates in Distilled Beverages

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Dimple Shah and Jennifer A. Burgess
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Application Notes
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Application Notes
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Phthalates, esters of phthalic acid, are often used as plasticizers for polymers such as polyvinylchloride. They are widely applicable in various products including personal care goods, cosmetics, paints, printing inks, detergents, coatings, and food packaging. These phthalates have been found to leach readily into the environment and food as they are not chemically bound to plastics. As such they are known to be ubiquitously present in our environment. Phthalates have been reported to show a variety of toxic effects related to reproduction in animal studies, which has resulted in these compounds being considered as endocrine disruptors. Screening food and beverages for phthalates contamination is required by many legislative bodies, although regulations vary from country to country in regards to acceptable daily tolerances and specific migration limits. In this application note phthalates were separated on a reversed-phase column within 11 minutes using UPLC coupled to a tandem quadrupole mass spectrometer. Limits of detection (LOD) and quantification (LOQ) of seven key phthalates (DEHP, BBP, DBP, DNOP, DEP, DMP, and DINP) in the sample are presented.

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