Increasing Specificity and Sensitivity in Routine Peptide Analyses Using Mass Detection with the ACQUITY QDa Detector

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Robert E. Birdsall and Sean M. McCarthy
Waters Corporation
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Developing efficient methods for the accurate assessment of CQAs that impact product efficacy and safety are highly desirable in the biopharmaceutical production environment. This study has demonstrated orthogonal detection techniques, such as mass detection, can be readily adapted to existing workflows for increased specificity and sensitivity in routine monitoring assays. The ACQUITY QDa Detector in conjunction with Empower 3 CDS Software affords a means for cost-effective mass detection, with increased productivity, and confidence in the development and analysis of routine monitoring assays.

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