UPLC SYNAPT MS/MS Method for Structural Characterization of siRNA Oligonucleotides

Library Number:
APNT10093909
Part Number:
720002869en
Author(s):
Vera Ivleva, Ying Qing Yu, Martin Gilar
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
 
SYNAPT HDMS
 
 
 

This application note presents the use of an exact mass UPLC/MS/MS analytical method for structural characterization of 21-nt-long RNA, using UPLC with Oligonucleotide Separation Technology Columns and the SYNAPT HDMS. The method is highly useful for confirmatory sequencing of siRNA base therapeutic compounds.


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