Investigating Gas Composition on Transport and Desolvation of High m/z Species in the First Vacuum Stages of a Mass Spectrometer

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Iain Campuzano and Kevin Giles
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Application Notes
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Technical Notes
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Here we present a method that provides efficient desolvation and effective transport of large biological ions from atmospheric pressure into the vacuum system of a mass spectrometer, through modification of the atmospheric pressure gas (cone gas) composition. No other source modifications were carried out in this work. Significant enhancements of the transmission and desolvation of large multiply-charged protein ions were achieved by changing the cone gas from nitrogen to a signficantly heavier polyatomic gas.

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