Solubility Screening by UPLC/MS/MS

Library Number:
APNT10070395
Part Number:
720002612en
Author(s):
Darcy Shave and Pete Alden
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
 
 
ACQUITY TQD
 
ACQUITY TQD
 

UltraPerformance LC (UPLC) technology can be used to measure compound solubility in either an aqueous buffer solution or mixtures of co-solvents with relatively high-throughput capability, while maintaining adequate accuracy of results.

Given the selectivity and sensitivity of MS/MS detection, UPLC/MS/MS analysis with the Waters ACQUITY TQD System in combination with specialized software, ProfileLynx and QuanOptimize Application Managers, is the ideal choice for quantitation of a solubility screen.

Using ProfileLynx and QuanOptimize Application Managers allowed for:

  • Automated MS method development and data acquisition
  • Single approach for data processing and report generation from multiple assays
  • Complete automated analysis, processing, and reporting
  • Increased laboratory throughput

 


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