Testing for GHB in Hair by GC Tandem Quadrupole MS

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Marie Bresson, Vincent Cirimele, Pascal Kintz, Marion Villain, Timothy Jenkins, Jean-Marc Joumier
Waters Applications Note
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Application Notes
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Application Notes
Related Products:
Quattro micro GC
Quattro micro GC
GHB has been misued from its intended therapeutic use by bodybuilders to increase muscle mass; by ravers because it produces euphoria and can balance some side-effects of the drug ecstasy; and by rapists in cases of sexual assault. GHB is detected in blood or urine within 6 to 12 hours of being administered. Hair analysis allows an increase in the detection window depending on the hair length. Recently, hair analysis was used to prove a single exposure. A sensitive, specific, and reproducible method has been developed to detect and quantify GHB in hair by gas chromatography and tandem quadrupole mass spectrometry, GC/MS/MS.

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