Utilizing the Speed and Resolution of UPLC to Enhance MS/MS Detection of HBCD & TBBP-A Diastereomers

Library Number:
APNT10009295
Part Number:
720002445en
Author(s):
Keith Worrall, Peter Hancock, Alwyn Fernandes, Malcolm Driffield, and Martin Rose
Source:
Waters Application Note
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
 
 
Fine and Specialty Chemicals
 
 
 

Brominated Flame Retardants (BFRs) are chemicals commonly used in many domestic and industrial appliances, equipment and textiles to increase their resistance to fire. There is current concern as to the persistent nature of these chemicals and consequently, the detrimental effects they may have. Various studies have shown a presence of HBCD and TBBP-A in the environment as well as in aquatic and human tissues. Both HBCD and TBBP-A are currently marketed around the world without any legislative restrictions. However, as emerging contaminants or Persistent Organic Pollutants (POPs), the importance of continuous monitoring to quantify the impact of these chemicals on human health and the environment is paramount. The application note describes a solution that provides increased resolution and shorter run times for the analysis of Hexabromocyclodecane (HBCD) and Tetrabromobisphenol-A (TBBP-A) diastereomers using UPLC-MS/MS.


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