Modernized Impurity Analysis of the Kinase Inhibitor Imatinib by High-Resolution LC With MS-Compatible Mobile Phases

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Peng Chen, Bonnie A. Alden, Matthew A. Lauber
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The use of UPLC with an ACQUITY Premier CSH Phenyl-Hexyl Column has facilitated the modernization of an EP method to analyze imatinib and its impurities. Considerations on L/dp and MS compatibility were applied to develop a separation that produces excellent peak shape and resolution for imatinib and nine of its impurities. Sensitive impurity analysis was made possible through both optical detection and accurate mass time-of-flight MS analysis.

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