Quantitative Analysis of Polysorbate 20/80 in Protein-Based Biopharmaceuticals Using A One-Pot RPLC-MS Based Platform Method

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Robert E. Birdsall, David Dao, Brooke M. Koshel, Ying Qing Yu, Aude Smeets, Michel Gerodez, Xavier Taillieu
Waters, GlaxoSmithKline
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Application Notes
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Application Notes
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This application note demonstrates an LC-MS-based hydrolysis method can be successfully deployed to detect polysorbate constituents at sub-ppm levels using a single quad mass spectrometer.

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