The Waters ACQUITY Premier System is the first to offer novel MaxPeak High Performance Surfaces (HPS)-based technology that provides a truly inert LC system and is holistically designed to complement the Waters sub-2-μm particle ACQUITY UPLC Premier Column family. This system represents the ultimate in chromatographic performance and confidence. The ACQUITY Premier System reduces variability and losses due to surface interactions, while avoiding time consuming passivation and/or additive use. The system also increases sensitivity, repeatability, and confidence in analytical results, ultimately leading to time savings, improved productivity, and better decision making. This configuration features the robustness and low dispersion of binary solvent management with direct-injection style sample manager. The ACQUITY Premier System is available with a choice of column management options.