Intact Trastuzumab Monoclonal Antibody Quantification Using the Xevo G2-XS QTof High Resolution Mass Spectrometer

Library Number:

APNT134994628

Part Number:

720006379EN

Author(s):

Yun Wang Alelyunas, Henry Shion, Ian Edwards, and Mark Wrona

Source:

Waters

Content Type:

Application Notes

Content Subtype:

Technical Notes

Related Products:

ACQUITY UPLC H-Class PLUS Bio System

DMPK: Drug Metabolism and Pharmacokinetics

Xevo G2-XS QTof Quadrupole Time-of-Flight Mass Spectrometry

UNIFI Scientific Information System

Abstract / Summary

This technology brief demonstrates the performance of the Xevo™ G2-XS QTof platform for intact level quantification of trastuzumab monoclonal antibody and the use of UNIFI™ for rapid data processing and analysis. In the present study, a monoclonal antibody, trastuzumab, was quantified at the intact level through integration of XICs, which follows common practice in small molecule and peptide bioanalysis.

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