HDX Publications
A list of top publications for all your HDX needs.
REVIEWS:
- Hydrogen deuterium exchange mass spectrometry in biopharmaceutical discovery and development - A review (2016)
- Conformational insight into multi-protein signaling assemblies by hydrogen-deuterium exchange mass spectrometry (2016)
- Technical decision making with higher order structure data: Perspectives on higher order structure characterization from the biopharmaceutical industry (2016)
- Applications of hydrogen/deuterium exchange MS from 2012 to 2014 (2015)
- Analytical aspects of hydrogen exchange mass spectrometry (2015)
- Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: Methodology and applications (2014)
- Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry (2013)
- The use of hydrogen/deuterium exchange mass spectrometry in epitope mapping (2013)
- Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars (2012)
- Hydrogen exchange mass spectrometry: Are we out of the quicksand? (2012)
- Easing the toil of hydrogen exchange (2012)
- Hydrogen exchange mass spectrometry: What is it and what can it tell us? (2010)
TECHNOLOGIES:
- Tuning a high transmission ion guide to prevent gas-phase proton exchange during H/D exchange MS analysis (2016)
- Pepsin immobilized on high-strength hybrid particles for continuous flow online digestion at 10,000 psi (2012)
- Site-specific analysis of gas-phase hydrogen/deuterium exchange of peptides and proteins by electron transfer dissociation (2012)
- ETD in a traveling wave ion guide at tuned Z-spray ion source conditions allows for site-specific hydrogen/deuterium exchange measurements (2011)
- Gas-phase hydrogen/deuterium exchange in a traveling wave ion guide for the examination of protein conformations (2009)
- High-speed and high-resolution UPLC separation at zero degrees Celsius (2008)
- Ion mobility adds an additional dimension to mass spectrometric analysis of solution-phase hydrogen/deuterium exchange (2008)
BIOSIMILARS:
- Physicochemical and biological characterization of SB2, a biosimilar of Remicade® (infliximab) (2017)
- Advanced assessment of the physicochemical characteristics of Remicade® and Inflectra® by sensitive LC/MS techniques (2016)
- Evaluation of the structural, physicochemical, and biological characteristics of SB4, a biosimilar of etanercept (2016)
- Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars (2012)
COMPARABILITY:
- A two-pronged binding mechanism of IgG to the neonatal Fc receptor controls complex stability and IgG serum half-life (2017)
- Removal of N-linked glycosylations at acidic pH by PNGase a facilitates hydrogen/deuterium Exchange mass spectrometry analysis of N-linked glycoproteins (2016)
- Isomerization and oxidation in the complementarity-determining regions of a monoclonal antibody: a study of the modification-structure-function correlations by hydrogen-deuterium exchange mass spectrometry (2016)
- Replication in bioanalytical studies with HDX MS: Aim as high as possible (2015)
- Characterization of stress-exposed granulocyte colony stimulating factor using ELISA and hydrogen/deuterium exchange mass spectrometry (2014)
- Understanding the conformational impact of chemical modifications on monoclonal antibodies with diverse sequence variation using hydrogen/deuterium exchange mass spectrometry and structural modeling (2014)
- Using hydrogen/deuterium exchange mass spectrometry to study conformational changes in granulocyte colony stimulating factor upon PEGylation (2012)
- Conformational comparability of factor IX-Fc fusion protein, factor IX, and purified Fc fragment in the absence and presence of calcium (2012)
- The utility of hydrogen/deuterium exchange mass spectrometry in biopharmaceuticalcomparability studies (2011)
- Post-translational modifications differentially affect IgG1 conformation and receptor binding (2010)
- Characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry (2009)
AGGREGATION:
- Characterization of aggregation propensity of a human Fc-fusion protein therapeutic by hydrogen/deuterium exchange mass spectrometry (2016)
- Investigating monoclonal antibody aggregation using a combination of H/DX-MS and other biophysical measurements (2013)
VIRUS AND VACCINES:
- Conformational changes in intact dengue virus reveal serotype-specific expansion (2017)
- Probing the impact of local structural dynamics of conformational epitopes on antibody recognition (2016)
- Isolate-specific differences in the conformational dynamics and antigenicity of HIV-1 gp120 (2013)
- HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck. (2012)
PROTEIN COMPLEXES:
- Force interacts with macromolecular structure in activation of TGF-β (2017)
- Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome (2016)
- Conformational insight into multi-protein signaling assemblies by hydrogen-deuterium exchange mass spectrometry (2016)
- Structural dynamics in ras and related proteins upon nucleotide switching (2016)
- Investigating the interaction between the neonatal Fc receptor and monoclonal antibody variants by hydrogen/deuterium exchange mass spectrometry (2015)
- GroEL/ES chaperonin modulates the mechanism and accelerates the rate of TIM-barrel domain folding (2014)
EPITOPE MAPPING:
- Conformational changes in intact dengue virus reveal serotype-specific expansion (2017)
- Mapping the energetic epitope of an antibody/interleukin-23 interaction with hydrogen/deuterium exchange, fast photochemical oxidation of proteins mass spectrometry, and alanine shave mutagenesis (2017)
- Probing the impact of local structural dynamics of conformational epitopes on antibody recognition (2016)
- Higher order structure characterization of protein therapeutics by hydrogen/deuterium exchangemass spectrometry (2014)
- Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: Methodology and applications (2014)
- Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen (2013)
- The use of hydrogen/deuterium exchange mass spectrometry in epitope mapping (2013)
MUTATIONS:
- Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG (2013)
- Analysis of the local dynamics of human insulin and a rapid-acting insulin analog by hydrogen/deuterium exchange mass spectrometry (2013)
PROTEIN LIGAND INTERACTIONS:
- β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated protein kinase (2016)
- Ligand-mediated changes in conformational dynamics of NpmA: implications for ribosomal interactions (2016)
- Predicting allosteric effects from orthosteric binding in Hsp90-ligand interactions: Implications for fragment-dased drug design (2016)
- Allosteric inhibition of antiapoptotic MCL-1 (2016)
- The influence of adnectin binding on the extracellular domain of epidermal growth factor receptor (2014)
- Dynamics of phosphodiesterase-induced cAMP dissociation from protein kinase A: Capturing transient ternary complexes by HDXMS (2013)
- Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors (2012)