Peptide Mapping and Small Protein Separations with Charged Surface Hybrid (CSH) C18 and TFA-Free Mobile Phases

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Matthew A. Lauber, Stephan M. Koza, Kenneth J. Fountain
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Xevo G2 QTof
Xevo G2 QTof

Peptide mapping with FA instead of TFA facilitates more sensitive detection using ESI-MS. As a result, the CSH 180 C18 column is ideal for LC/MS-based peptide mapping because its performance is excellent with either acid modifier. Greater peak capacity and unique selectivity are added benefits of the CSH column.

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