Utilizing UPLC/MS for Conducting Forced Degradation Studies

Library Number:
720002259EN
Part Number:
720002259EN
Author(s):
Peter Alden, Michael Jones, Paul Lefebvre, Rob Plumb (Waters)
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
 
 
ACQUITY SQD
 
 
ACQUITY SQD

In this application note, we have demonstrated the ability of an ACQUITY UPLC system combined with an ACQUITY UPLC PDA and SQ mass spectrometer to separate degradation products in a pharmaceutical product, such as simvastatin. These high peak capacity separations for complex mixtures of degradation products result in faster analyses, improve identification of impurity products and shorten the time required to develop stability indicating methods, improving the quality and throughput of forced degradation studies.

 


Title Format File Size
Download (720002259en) PDF 859.6kB