Metabolite Identification of Complex Cyclic Peptides Using WebMetabase, Ion Mobility-Enabled DIA, and Product Ion Confirmation

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Mark Wrona
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Application Notes
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Application Notes
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In this application note, we describe a solution that uses an information-rich data acquisition mode, which effectively deals with the complexity of modified peptides. This enables key metabolic data to be generated unambiguously while tackling complex peptide studies. The use of DIA combined with ion mobility (HDMSE) improves upon the selectivity provided by MS-only techniques. The addition of routine Collision Cross Section (CCS) measurements makes HDMSE a powerful identification acquisition mode, as well as an ideal separation technique.

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