Sub-pg/mL Bioanalytical Quantification of Fluticasone Propionate Using the ACQUITY UPLC I-Class System and Xevo TQ-XS Tandem Quadrupole Mass Spectrometer with UniSpray Ionization

Library Number:
APNT135003353
Part Number:
720006422EN
Author(s):
Taposh Gorrela, PMN Rajesh, Dr. Padmakar Wagh
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Technical Notes
Related Products:
 
 
 
ACQUITY UPLC I-Class System

In this work, a simple sample preparation strategy with Oasis MCX SPE combined with UPLC chromatographic separation ACQUITY UPLC I-Class System, and sensitivity MS analysis, using the Xevo TQ-XS Mass Spectrometer was used to successfully quantify fluticasone propionate from plasma.

The Xevo™ TQ-XS quadrupole Mass Spectrometer used for quantification of fluticasone propionate (extracted from human plasma) achieved excellent sensitivity and dynamic range, demonstrating its suitability for bioanalytical quantification.


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